Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
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چکیده
منابع مشابه
Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome
Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been associated with various human cancers. In contrast, we show here that a mutant strain of the model fungus Aspergillus nidulans deficient in two deneddylases is viable but can only grow as a filament and is highly impaired for multicellular development. The DEN1/DenA and the CO...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1003275